Project description

Project Structure

  • Characterize the gene expression profile of symptomatic and asymptomatic plaques
  • Determine the cellular composition of atherosclerotic plaques through deep profiling
  • Assess the predictive value of ceramides in carotid artery disease
  • Assess the predictive value of extracellular vesicle biomarkers in carotid artery disease
  • Identify common pathways and networks through joint modelling of multi-omics datasets that cluster plaques into biologically and clinical risk-relevant subtypes
  • Determine circulating biomarker profiles that can be used as surrogate markers to identify distinct plaque subtypes
  • Describe carotid artery disease endotypes and use them to refine patient stratification according to risk
  • Refine the existing multilevel computational model of plaque progression
  • Develop an agent based model of plaque progression
  • Integrate models outcomes and delivery of the new risk stratification tool
  • Validate the individual models and the new risk stratification tool
  • Select the most informative pharmacogenetic markers for patient stratification and personalized (precision) treatment
  • Fabricate the single cavity pipet PCR devices and thermal controller in order to enable the different temperature steps (PCR cycling)
  • Fabricate the fluidic testing of multiple cavity lab-on-a-chip
  • Optimize the individual PCR reactions on lab-on-a-chip
  • Demonstrate the multiplex PCR using a single lab-on-a-chip
  • Run a prospective observational clinical study in patients with carotid artery disease
  • Evaluate the predictive performance of the new risk stratification model
  • Assess the ability of the new risk stratification model to reduce unnecessary treatment, morbidity and healthcare costs
  • Define and follow the legal, ethical, and data protection, privacy and security issues related with the clinical and research activities
  • Identify and analyse the regulatory aspects influenced by the introduction of TAXINOMOSIS approach
  • Measure and quantify the increased cost-effectiveness of TAXINOMISIS concepts in comparison to the already established practices
  • Implement a strong plan for the exploitation and commercialisation of the scientific and technological results.
  • Accelerate the transition of the biomedical and clinical research results to medical use through well-defined
  • Present dissemination and communication activities
  • Introduce and enhance the penetration of the TAXINOMISIS results to the industry driven field and specifically to the small and medium SMEs of lab-on-chip technologies and disease prediction tools
  • Share the gained knowledge with key stakeholders, including patient associations, public health authorities, regulatory experts and others
  • Keep a well-organized communication between consortium partners
  • Ensure an efficient financial administration of project resources
  • Release the project deliverables on time respecting project constraints and ensuring results quality
  • Monitor the partners activities and timely conflict resolution
  • Ensure compliance with the 'ethics requirements' set out in this work package
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This project has received funding from the
European Union’s Horizon 2020 Research and
Innovation Programme under grant agreement No
755320