TAXINOMISIS aims to develop a new concept for the carotid artery disease stratification by analysing the pathobiology of symptomatic plaques, identifying disease mechanisms and developing a multiscale risk stratification model, which integrates clinical and personalized data, plaque and cerebral image processing and computational modelling and novel biomarkers for high vs low risk states, in order to address the needs for stratified and personalised therapeutic interventions in the current era. This approach will be the first of its kind in cardiovascular and other chronic diseases in general, and will have a strong “personalized” element, exploring the biology of atherosclerotic plaques and circulating biomarkers in the same patient, combined with heterogeneous individual/patient-specific clinical, imaging and demographic information.